Medical bedsore prevention mattress is helpful to prevent bedsores caused by long-term bed rest, and is suitable for medical maintenance institutions. The medical bedsore-preventing mattress consists of a silent air pump, an independent inflatable air chamber and a waterproof and breathable bedspread. Its working principle is that multiple air chambers exhaust alternately, so that patients' skin can contact air and gas circulation alternately, reduce heat generation and humidity, and create a comfortable sleeping environment.