Causes of acute pancreatitis in children
The causes of acute pancreatitis in children are different from those in adults. The most common causes are as follows.
1. Drug-induced:
The application of large amounts of adrenal hormones, immunosuppressive drugs, morphine, and the application of L-asparagine in the treatment of acute lymphoblastic leukemia can cause acute pancreatitis.
2. Secondary bacterial or viral infection in other parts of the body:
Such as acute mumps, pneumonia, bacillary dysentery, tonsillitis, etc.
3. Upper gastrointestinal disease or malformation of the biliopancreatic junction:
Bile refluxes into the pancreas, causing pancreatitis.
4. Others:
However, there are still some cases without certain causative factors.
[What are the symptoms of pancreatitis in children] Causes of chronic pancreatitis in children
1. Chronic calcific pancreatitis:
(1) Hereditary pancreatitis Inflammation: It is an autosomal recessive genetic disease. The gene for hereditary pancreatitis is located on the long arm of chromosome 7. Arginine at position 117 of trypsinogen is replaced by histidine, causing autodigestion of the pancreas and inducing pancreatitis.
(2) Adolescent tropical (nutritional) pancreatitis: It is a common cause in children. It is found in some people with insufficient nutritional intake in southern India, Indonesia, and tropical areas near the equator of Africa. The reason is malnutrition and consumption of cassava flour, which contains toxic glycosides.
2. Chronic obstructive pancreatitis:
(1) Pancreatic schisis: The incidence of pancreatic schisis in the general population is 5% to 15%, and it is the most common disease of the pancreas. Common deformities. Because the dorsal and ventral pancreatic primordia cannot fuse, the pancreatic tail, pancreatic body, and part of the pancreatic head are drained through the relatively narrow accessory pancreatic duct instead of through the main pancreatic duct.
(2) Abdominal trauma: After abdominal trauma, hidden damage to the pancreatic duct can lead to stenosis, pseudocyst formation and chronic obstruction.
3. Idiopathic fibrosing pancreatitis:
Idiopathic fibrosing pancreatitis is very rare and may cause abdominal pain or obstructive jaundice. Diffuse fibrous tissue hyperplasia can be seen in the glands.
4. Others:
Children with hyperlipidemia types I, IV, and V can develop pancreatitis. Transient hyperlipidemia can occur during pancreatitis, so elevated blood lipids during acute pancreatitis must be retested after improvement. Other causes include gallbladder fibrosis, sclerosing cholangitis, inflammatory bowel disease, etc.
[Treatment of pancreatitis in children] Preventive measures for acute pancreatitis in children
1. Prevent the occurrence of infectious diseases, such as biliary roundworms, viral infections, sepsis, mycoplasma pneumonia and other diseases.
2. Prevent overeating and malnutrition to avoid gastrointestinal dysfunction, which may impede the normal activity and emptying of the intestines, hinder the normal drainage of bile and pancreatic juice, and cause pancreatitis.
3. Avoid or eliminate biliary tract diseases: promptly treat biliary stones and prevent intestinal roundworms.
4. Avoid upper abdominal damage, such as surgical endoscopic retrograde pancreatography, etc.
5. Prevent and treat metabolic disorders, such as hypercalcemia, hyperlipidemia, diabetes, etc.
6. Others: such as prevention and treatment of alcoholism, trauma, emotions, drugs and other factors. Preventive measures for chronic pancreatitis in children
1. Hereditary chronic recurrent pancreatitis should be well consulted on genetic diseases.
2. Adolescents with tropical pancreatitis should prevent protein malnutrition and maintain a balanced diet.
3. Prevent hyperlipidemia and hypercalcemia.
4. Prevent vitamin D poisoning and overnutrition.
5. At the same time, acute pancreatitis should be treated thoroughly to prevent the disease from being delayed.
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