The annual interest rate is 5%, and the annual return is 250,000. The annual interest of a 5 million loan depends on the interest rate and repayment method of the loan. According to the annual interest rate of 5%, the annual interest of a loan of 5 million yuan is 250,000 yuan. The calculation method is: the principal of 5 million yuan multiplied by the annual interest rate of 5% equals the interest.