Generally speaking, the comprehensive strength of Nanning will be stronger than that of Guiyang in 2022. Here are some specific comparisons:

1.GDP: In the first quarter of 2022, Nanning's GDP was 125076 billion yuan, ranking 56th, and Guiyang's GDP was 1086 billion yuan, ranking 78th. This shows that Nanning's GDP exceeds Guiyang in ranking.

2. Per capita: Nanning's per capita indicators are better than Guiyang's, including per capita GDP and per capita income.

3. Medical and educational resources: Nanning is rich in medical and educational resources, which is superior to Guiyang.

To sum up, according to the data in 2022, the comprehensive strength of Nanning is still relatively strong.