C- alkylation was first discovered by French chemist friedel and American chemist Kraft in 1877. When anhydrous aluminum trichloride is added to benzene and methyl chloride, a strong reaction occurs, hydrogen chloride gas is released, and toluene is separated from the reaction mixture. Alkylation of benzene to toluene is the simplest example.
C- alkylation is a kind of alkylation reaction, which can be used to synthesize a series of alkyl-substituted aromatic hydrocarbons and is widely used in laboratory and industry.
Extended data:
Alkylation is one of the important reactions in organic synthesis. For example, the preparation of chemical raw materials such as N, N- dimethylaniline and anisole is realized by alkylation.
1, aniline and methanol react to prepare n, N- dimethylaniline. N, N- dimethylaniline is the main intermediate for the synthesis of basic dyes, and it is also an important raw material for the synthesis of medicines, spices and explosives. The alkylation reaction formula is:
2. Anisoether can be prepared by alkylation of phenol with dimethyl sulfate. Anisoether is mainly used for preparing essence and organic synthesis. The alkylation reaction formula is:
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